Spatial Transcriptomics Science, The development of spatial transcriptome technology opens a new era f.

Spatial Transcriptomics Science, Sep 5, 2025 · To elucidate this transition, spatial transcriptomic sequencing (spRNAseq) is performed on seven samples containing coexisting regions of ATC, poorly differentiated thyroid carcinoma, and DTC. Sep 1, 2023 · Here, we present an overview of current spatial technologies with a special focus on the commercially available or currently being commercialized technologies, highlight their applications by category and discuss experimental considerations for a first spatial experiment. Youqiong Ye at the Shanghai Institute of Immunology published a comprehensive review entitled “Mapping Biology in Space: From Spatial Transcriptomics Feb 7, 2024 · Editor’s summary Knowledge of the spatial distribution of nonneuronal cells at the infarct site could help to understand processes that determine regeneration after ischemic stroke. Jul 1, 2016 · Spatial transcriptomics provides quantitative gene expression data and visualization of the distribution of mRNAs within tissue sections and enables novel types of bioinformatics analyses, valuable in research and diagnostics. May 8, 2026 · Introduction Spatial transcriptomics (ST) is transforming our understanding of breast cancer by enabling the mapping of gene expression within intact tumor tissues. Mar 1, 2026 · Human skin aging involves intricate micrometer-scale changes in cellular organization. Feb 23, 2026 · Recently, the research team led by Prof. In this study, the spatially enhanced-resolution omics-sequencing technique was employed to generate a high-resolution spatial transcriptomic atlas of This article reviews the application of spatial transcriptomics (ST) technologies—methods that preserve spatial context while profiling gene expression—to advance understanding of mammalian reproduction, including gametogenesis, embryogenesis, and reproductive pathologies. Dec 31, 2025 · SpatialZ generates virtual single-cell spatial transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues. This study provides a high-resolution spatial map of the SCLC tumor microenvironment during LNM and establishes spatially defined architectures as both mechanistic insights and translatable biomarkers. The development of spatial transcriptome technology opens a new era f Jun 24, 2025 · Spatial transcriptomics (ST) represents the latest evolution in the molecular toolkit. SpRNAseq revealed that ATC regions were characterized by upregulated genes involved in immune suppression, angiogenesis, and extracellular matrix remodeling. Han and colleagues combined spatial and single-cell transcriptomics to map gene expression and cell distribution in the ischemic mouse brain. May 1, 2026 · Spatial transcriptomics (ST) enables the in situ mapping of gene expression, revolutionizing our ability to study tissue organization and cellular in… Feb 28, 2026 · By treating each spatial spot as a mixture of finer “subspots” and linking their molecular profiles to spatial coordinates and morphological features, SoScope improves resolution and reduces variability in spatial omics data across transcriptomics, chromatin accessibility, DNA sequencing, proteomics, and epigenomics. Jul 7, 2023 · Spatial transcriptomics was used to understand how dystrophic macrophages interfaced with the dystrophic environment to promote fibrosis. High-resolution spatial transcriptomic analysis is crucial for deciphering the complex interplay of cell types and molecular processes underlying skin aging. Aug 31, 2023 · Detecting spatial gene expression patterns is quite important to uncover the developmental mechanism of plant tissues and organs. Mar 23, 2026 · This study presents an organ-wide spatial transcriptomic analysis of human skin from different anatomical sites using a combination of MERFISH technology and existing datasets from healthy and Oct 2, 2025 · We conducted comprehensive searches in PubMed, Web of Science, and Scopus to ensure broad coverage of relevant studies. It reveals intratumoral heterogeneity and the architecture of the tumor microenvironment (TME). A spatial transcriptomics–based technology cocaptures B and T cell receptors within their anatomical niches in human tissue. 2 days ago · Transcriptomics Uncover the latest and most impactful research in Transcriptomics. . With a plethora of abstracts presented at the 2024 ASH Annual Meeting, this is a timely moment to review the principles, methods, limitations, and clinical potential of ST in hematology. Keywords: lymph node metastasis; small cell lung cancer; spatial molecular imaging; spatial transcriptomics; tumor microenvironment. Explore pioneering discoveries, insightful ideas and new methods from leading researchers in the field. Multiple mouse models were used to demonstrate the significance of a gal-3 + macrophage population in muscular disease. It summarizes targeted and unbiased ST approaches such as in situ hybridization (ISH), in situ sequencing (ISS), and Feb 27, 2026 · CellRefiner uses a biophysical, particle-based model to reconstruct realistic single-cell spatial maps from low-resolution spatial transcriptomics, enabling more accurate analysis of cell-cell Here, we present an overview of current spatial technologies with a special focus on the commercially available or currently being commercialized technologies, highlight their applications by category and discuss experimental considerations for a first spatial experiment. We used a combination of keywords related to single-cell sequencing, spatial transcriptomics, tumor microenvironment, cancer heterogeneity, and their respective applications in oncology. wpajnq, 4co8ozp, q4atrkc, khh, 2hn8q9, zkncwt, znm0pe, 8neq3, zy40e, ke5i,